Note: The job is a remote job and is open to candidates in USA. Guardant Health is a leading precision oncology company focused on guarding wellness and giving every person more time free from cancer. The Senior Security Engineer will be responsible for designing, implementing, operating, and continuously improving Guardant Health’s core security capabilities, ensuring the company has the right tools and processes to detect, prevent, respond to, and recover from security threats.
Responsibilities
- Design, implement, operate, and continuously improve enterprise security tools across Endpoint, Cloud, Identity, Network, SaaS, Vulnerability Management, Logging, and Response platforms
- Oversee and optimize Managed Detection and Response (MDR), as well as Security Orchestration, Automation, and Response (SOAR), capabilities and related integrations
- Serve as a technical owner for SIEM operations, including log source onboarding, data normalization, detection support, performance tuning, cost optimization, and regulatory logging requirements
- Develop, tune, and maintain high-value Threat Detection content, including SIEM rules, behavioral analytics, endpoint detections, cloud detections, and identity-based alerts
- Analyze security events, threat intelligence, and attacker tradecraft to improve detection coverage, validate alert effectiveness, and support incident response investigations
- Support and participate in Incident Response activities, including triage, investigation, containment, eradication, recovery, evidence collection, and post-incident reviews
- Support security investigations involving endpoint activity, cloud events, identity logs, network telemetry, SaaS activity, and other relevant data sources
- Provide expertise on EDR tooling including policy configuration, telemetry ingestion, detections, response actions, host containment, and integrations with other security systems
- Support Vulnerability Management activities, including scanner operations, asset coverage, vulnerability validation, risk prioritization, remediation tracking, exception handling, and reporting
- Manage threats from AWS and cloud-native environments, including monitoring and respond to CloudTrail, VPC Flow Logs, workload logs, IAM activity, container activity, and cloud security findings
- Build dashboards, metrics, and reports to measure Security Tool health, detection coverage, Vulnerability Management posture, Incident Response effectiveness, and overall security program maturity
- Develop and maintain documentation, operational runbooks, incident response playbooks, engineering standards, and tool administration procedures
- Evaluate AI-assisted security capabilities for detection, response, vulnerability management, and automation, while helping define how AI systems, agents, and usage are logged, monitored, and assessed for risk
- Provide technical leadership, mentorship, and guidance to junior engineers, analysts, and cross-functional partners
- Stay current on emerging threats, attacker tradecraft, vulnerability trends, Security Tooling, Cloud Security practices, and Security Engineering best practices
Skills
- 5+ years of experience in Security Engineering, Security Operations, Incident Response, Vulnerability Management, Detection Engineering, or a related security role
- Broad hands-on experience administering and improving enterprise security tools
- Experience supporting Incident Response in a SOC or enterprise security environment
- Strong experience with SIEM platforms, including log ingestion, alerting, detection content, dashboards, and operational support
- Experience with EDR platforms, including investigation, containment, policy management, and response workflows
- Experience with Vulnerability Management platforms and processes, including vulnerability scanning, prioritization, remediation tracking, and reporting
- Hands-on experience securing and monitoring AWS or other cloud environments
- Experience working with identity and access logs, preferably including Okta or similar identity platforms
- Strong understanding of endpoint, cloud, identity, network, SaaS, and infrastructure security telemetry
- Experience developing documentation, runbooks, playbooks, and repeatable operational procedures
- Experience modernizing SIEM, Logging, or Security Monitoring architectures
- Experience with detection engineering frameworks such as MITRE ATT&CK
- Experience building or managing SOAR workflows, response automation, or security orchestration
- Experience with cloud security posture management, cloud workload protection, container security, or infrastructure-as-code security tools
- Understanding of AI and machine-learning use cases in security, including detection, automation, monitoring, and governance considerations
- Strong written and verbal communication skills, with the ability to explain security risks and technical issues to both technical and non-technical stakeholders
- Experience in healthcare, biotech, life sciences, or other regulated environments a plus
- Familiarity with compliance and regulatory requirements that influence Security Logging, Monitoring, Vulnerability Management, and Incident Response a plus
Benefits
- Hybrid Work Model: defined days for in-person/onsite collaboration and work-from-home days
- All U.S. employees who live within 50 miles of a Guardant facility will be required to be onsite on Mondays, Tuesdays, and Thursdays
Company Overview