Note: The job is a remote job and is open to candidates in USA. Praxis Precision Medicines is a clinical-stage biopharmaceutical company developing therapies for central nervous system disorders using genetic insights. The Clinical Development Leader will provide clinical leadership across lifecycle management and early-phase development, shaping opportunities, leading clinical studies, interpreting data, and driving development decisions across the pipeline.
Responsibilities
- Lifecycle strategy: Identify and drive opportunities to expand the impact of late-stage and marketed assets, including new indications, label expansion, and formulation opportunities
- Early development: Lead first-in-human and dose-escalation studies, applying PK/PD and emerging clinical data to dose selection, decision rules, and next-stage development
- Clinical entry: Drive the clinical strategy and content for IND-enabling submissions and the decisions required to move programs into human studies
- Pipeline-wide leadership: Work credibly across mechanisms, indications, and phases, quickly developing the context needed to make sound clinical development decisions
- Data-driven decisions: Interpret emerging clinical and scientific data, identify what matters, and make timely calls when information is incomplete
- Cross-functional and external leadership: Drive teams across clinical operations, biostatistics, regulatory, safety, translational sciences, and other disciplines, while representing Praxis credibly with investigators, KOLs, health authorities, and partners
Skills
- An advanced scientific degree (MD, PharmD, PhD, or equivalent) is required
- A track record of clinical trials, programs, submissions, or major development decisions that you personally led
- Regulatory submission ownership having carried the clinical content of IND, CTA, NDA, or MAA filings, briefing books, and health authority interactions
- Strong judgment and the ability to make thoughtful, timely calls on emerging data with incomplete information and the knowledge of what to escalate and when
- Comfort operating in a dynamic environment where priorities shift, scope evolves, and ownership matters more than rigid role boundaries
Benefits
- This position may be performed remotely
- 99% of the premium paid for medical, dental and vision plans
- Company-paid life insurance, AD&D, disability benefits, and voluntary plans to personalize your coverage
- Dollar-for-dollar matching up to 6% on eligible 401(k) contributions
- Long-term stock incentives and ESPP
- A discretionary quarterly bonus
- An extremely flexible wellness benefit
- Generous PTO, paid holidays and company-wide shutdowns
Company Overview