Note: The job is a remote job and is open to candidates in USA. Kikiktagruk Inupiat Corporation is seeking a senior-level Bioassay SME Consultant to provide strategic and technical guidance for NIH drug discovery and development programs. The role will evaluate, optimize, and validate bioactivity assays; advise multidisciplinary Lead Development Teams; and support projects spanning lead optimization, preclinical safety, IND-enabling activities, and early clinical development.
Responsibilities
- Evaluate bioactivity assays and recommend strategies and experiments to optimize and validate assays supporting medicinal chemistry campaigns
- Establish and advise on milestones for assay optimization and validation
- Provide guidance on the design and interpretation of commonly used in vivo assays, including cognitive and behavioral tests
- Identify assay-related developmental challenges and recommend practical strategies to address them within realistic timelines
- Advise, strategically plan, and help manage programs spanning lead optimization, IND-enabling activities, and early clinical development
- Serve as a technical resource to LDT members regarding assay requirements, development strategy, and logistics for drug development activities
- Collaborate with NIH staff, consultants, CROs, and other partners on investigative studies supporting development compounds
- Participate actively in LDT meetings, which generally occur by teleconference for approximately two hours every one to two weeks
- Prepare for and contribute to LDT activities, with individual projects generally requiring approximately 3-10 hours per week, including meeting and preparation time
- When requested, accompany NIH staff on visits to CRO facilities, assist with evaluation of facilities and proposed methodologies, and prepare trip reports
- Work collaboratively across projects ranging from exploratory research through preclinical safety and, for selected programs, IND and clinical-stage development
Skills
- Advanced degree in a scientific discipline
- 15+ years of assay development experience in a pharmaceutical industry setting
- 15+ years of experience applying automated technologies and robotics relevant to pharmaceutical assays
- Broad experience applying diverse cellular techniques in pharmaceutical assays
- Extensive experience managing or serving as a senior leader on drug discovery projects within the biopharmaceutical industry
- Demonstrated experience working effectively with multidisciplinary teams at a senior level, including teams involving external organizations and stakeholders at varying management levels
- Strong ability to work collaboratively and manage competing priorities
- Excellent interpersonal, written, verbal, presentation, organizational, and documentation skills
- Strong computer and software literacy
- Ability to educate multidisciplinary team members, build trust, develop consensus, and maintain focus on program milestones
- Ability and willingness to participate actively in Lead Development Team discussions
- Experience in neuroscience drug discovery and development
- Experience developing therapeutics for pain
- Experience with both small-molecule and biologic therapeutics for pain relief
Benefits
- Remote work
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