Brain Shuttle AOC Consultant
Nucyrna Therapeutics | Boston, MA (remote-friendly) | Part-time consulting
About Nucyrna Therapeutics
Nucyrna Therapeutics is an RNA therapeutics company at the Pagliuca Harvard Life Lab in Boston, developing brain-penetrant oligonucleotide therapeutics for CNS diseases. Nucyrna Therapeutics leverages blood-brain barrier (BBB) shuttle technologies to deliver novel oligonucleotide payloads to the brain.
About the Role
We are seeking an experienced consultant to support our CRO-based research on brain-shuttle AOCs. You will support execution and interpretation of mouse PK and PD studies, advise on AOC design and in vivo study strategy.
Responsibilities
Design and review mouse PK/PD studies, including dosing, timepoints, and bioanalytical and PD assays
Provide scientific oversight of CRO activities, including protocol review, data QC, and troubleshooting
Advise on AOC design, including antibody or Fab format, conjugation strategy, and payload (siRNA or ASO)
Qualifications
Required:
Direct experience with AOCs, including testing in mice for PK and PD
Preferred:
Experience in antibody or Fab engineering
Experience managing CROs for in vivo studies
Familiarity with brain shuttles (for example, TfR-targeting) and CNS oligonucleotide delivery
Track record of publications or patents in related areas
Engagement
Remote, with occasional virtual meetings (on-site optional)
Compensation commensurate with experience
How to Apply
Please apply through this short Google Form: https://forms.gle/QV4i3LmcSFj6cGNQ8