Who We Are & What We Do
At Helix, our mission is simple: to help everyone improve their lives through
their DNA.
Ready to make a real-world impact with your skills? At Helix, we're transforming
healthcare by making genomics a standard of care. We partner with health systems
and life science companies to accelerate the integration of genomic data into
clinical practice. Join us in building a future where healthcare is
personalized, proactive, and powered by genomics.
What is special about this role?
You'll bridge the gap between genomic variants and the clinical answers that
help patients act on their DNA. You'll partner with scientists and product
leaders to turn promising prototypes into production systems that scale. Your
code will power how Helix automates gene and variant curation for real patients.
We have openings for both Senior and Staff level Engineers. You may apply at
either level, and we’ll consider your experience, qualifications and
demonstrated scope when determining the right level.
As a Senior/Staff Bioinformatics Engineer, Clinical Applications, you will:
Productionize curation workflows that support both classical and modern AI/ML
approaches to variant classification.
Automate evidence integration from sources such as ClinVar, gnomAD, and
PubMed.
Collaborate closely with scientists, product, and clinical stakeholders to
ensure software solutions meet scientific and product requirements.
Direct AI coding agents to accelerate development of curation pipelines,
applying engineering judgment to validate correctness, security, and
architectural fit before deployment.
At Senior level, own defined projects end to end, make technical decisions
within agreed priorities and architecture, and raise trade-offs that affect
broader systems.
At Staff level, independently frame ambiguous problems, set technical
direction, and make consequential architecture and prioritisation decisions
across the product area.
About you:
Bachelor's degree in Science or related field with 7+ years (Senior) or 9+
years (Staff) of professional software development experience. Or, a Master's
or Ph.D. with 3+ years (Senior) or 5+ years (Staff) of professional software
development experience.
Advanced proficiency in production-quality Python, relational databases, and
cloud platforms such as AWS.
Experience productionizing and scaling AI/ML software, especially agentic
systems built with frameworks such as LangChain or LangGraph.
Experience collaborating with scientists to integrate bioinformatics/NGS
tools and databases into production workflows.
Strong judgment evaluating AI-generated code and pipeline logic for
correctness, security, and maintainability before it reaches production.
Pluses:
Experience in clinical genomics, such as ACMG guidelines, clinical
diagnostics, or Human Phenotype Ontology (HPO) terms.
Experience developing regulated software, such as software as a medical
device.
At Staff level, the role may have the opportunity to take on people
leadership responsibilities. Experience mentoring or managing others, or an
interest in developing as a people leader, is a plus.
Expected Interview Process:
1) Recruiter Screen 2) Manager Screen/Tech Screen 3) Onsite 4) Offer
Expected Pay For This Role:
There are 3 distinct parts to your Helix offer: 1) Base Salary 2) Annual
Bonus 3) Equity
Expected Helix Base: $161,500 - $219,625
Expected Helix Discretionary Annual Bonus: 15% of your annual salary
Equity: We offer generous equity at Helix. If you receive a Helix offer your
recruiter will book dedicated time with you to educate you on our equity
model.
Aside from working alongside brilliant, dedicated, passionate, down-to-earth,
curious, warm, and thoughtful people, we also provide great benefits:
Comprehensive Health Insurance with Date of Hire eligibility
Above average employer paid premium coverage
12 weeks Helix Paid Parental Leave option
401(k) with employer matching of up to 3% and 100% Vesting on the Date of
Hire
Comprehensive Well-Being Benefits
Flexible PTO
Remote options for many roles and a home office stipend
What To Expect During Your First 90 days:
First 30 days: you’ll spend time learning the Helix way, completing training
and onboarding for your roles, and getting introduced to your team and
relevant stakeholders. You’ll also gain a deeper understanding of our
customers, our products, the impact we make in the lives of our communities,
and how to thrive at Helix through participation in Helix U.
Day 30 - 60: you’ll spend time contributing to projects, deeply familiarizing
yourself with team and company processes, and developing a deeper
understanding of Helix’s products, services and capabilities.
Day 60 - 90: you’ll build your OKRs with your manager, start to take
ownership of projects and initiatives on your team, and begin to demonstrate
your impact on the Helix mission.
To learn how Helix collects, uses, and protects your personal information during
the recruitment process, please review our Privacy Notice
[https://www.helix.com/privacy-policy].
Helix is proud to be an equal opportunity employer, and committed to providing
employment opportunities regardless of race, religious creed, color, national
origin, ancestry, physical disability, mental disability, medical condition,
genetic information, marital status, sex, gender, gender identity, gender
expression, pregnancy, childbirth and breastfeeding, age, sexual orientation,
military or veteran status, or any other protected classification, in accordance
with applicable federal, state, and local laws.
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