Posted Oct 21, 2026

Senior Technical Program Manager

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Senior Technical Program Manager X4 Life Sciences are partnered with a fast-scaling biosimulation company on the search for a Senior Technical Program Manager. The company builds software that helps life sciences teams make better decisions earlier in their work. The science is complex, the technology is moving fast, and the business is at the stage where how work gets planned and delivered matters as much as what gets built. This is a remote role, and a hands-on one. You’ll sit between scientists, software and data engineers, and the executive team, turning ambitious objectives into workstreams that ship. You’ll need enough technical depth to ask the right questions and spot a risk before it becomes a problem. You won’t need to be the expert in every discipline. What you’ll own Complex, cross-functional programmes from definition through delivery, spanning AI and ML, engineering, computational science and translational work Turning scientific, product and client goals into workstreams with clear owners, milestones, dependencies and budgets Writing scopes of work and estimates that the team can deliver, built with the scientific and technical leads Owning programme budgets from proposal through delivery, tracking actuals and forecasts with commercial and finance Catching scope changes early and reflecting them in timelines, resources and contracts Running programme reviews that focus on decisions, risks and budgets rather than status What we’re looking for 7+ years experience in in technical programme, engineering programme or technical product management Experience running programmes involving software, data, AI/ML or computational science teams, including getting scientists and engineers to deliver together Ability to understand technical architecture, dependencies and trade-offs A track record of rescuing at-risk programmes and challenging senior leaders when scope, timelines or assumptions don’t hold Experience running multiple technical workstreams at once, and managing budgets, forecasts and resource allocation Experience writing project plans, scopes of work, resource estimates and budgets Experience setting up planning, review and budget processes from scratch that teams actually use Ability to get up to speed quickly in an unfamiliar scientific or technical domain Regular use of LLMs and AI tools in your own work, with the judgement to check outputs Nice to have Experience in biotech, biopharma, computational biology, scientific software or healthcare technology Familiarity with machine learning and modern AI development workflows Experience writing SOWs or proposals for pharmaceutical, biotech or government clients Time in an early or growth-stage technology company If you are interested, please apply, and reach out to me at o.archer@x4lifesciences.com