Note: The job is a remote job and is open to candidates in USA. Sequencing is building the interface between humanity and its DNA. As a Senior AI Bioinformatics Engineer, you will design and build distributed services and genomic reasoning engines that enable AI to accurately reason about genes, variants, and human health.
Responsibilities
- Design and build the production AI systems powering Sequencing AI
- Develop distributed backend services, genomic reasoning engines, and retrieval systems that combine bioinformatics with modern AI
- Serve as the bioinformatics expert on the AI Team, helping shape how genomic knowledge is represented, retrieved, reasoned over, and validated throughout the platform
- Design how AI represents, retrieves, and reasons over genomic knowledge to deliver accurate, explainable, and scientifically grounded responses
- Build scalable services that enable AI to accurately reason over genes, variants, diseases, medications, and scientific literature
- Design high-performance data models, indexing strategies, and storage architectures across PostgreSQL, Qdrant, Redis, DuckDB, and Apache Spark
- Develop guardrails and deterministic reasoning layers that keep AI responses scientifically accurate, explainable, and grounded in genomic evidence
- Translate complex bioinformatics and genomic knowledge into scalable, production-ready software
- Collaborate with Senior Backend Engineers to architect AI systems that are fast, reliable, and built to scale
- Work closely with the Bioinformatics team to integrate genomic annotations, interpretation logic, and scientific knowledge into the AI platform
- Continuously improve the platform’s scientific accuracy, performance, and capabilities as AI and genomic science evolve
Skills
- 5+ years designing, building, and operating production backend systems at scale
- Expert-level TypeScript with experience owning production services end to end
- Strong distributed systems fundamentals - you understand how they're designed, scaled, and why they fail
- Hands-on experience building large-scale data processing systems using technologies such as Apache Spark and processing very large datasets
- Deep experience designing high-performance data architectures using PostgreSQL, DuckDB, Redis, and similar technologies
- Experience building distributed, event-driven systems using technologies such as AWS SQS, RabbitMQ, or BullMQ
- Experience building production AI systems, including retrieval architectures, vector databases, LLM APIs, and AI evaluation
- A passion for software craftsmanship, building systems that prioritize correctness, performance, maintainability, reliability, and scale
- Deep expertise in human whole genome sequencing and genomic interpretation
- Extensive experience working with VCFs, genomic annotations, and variant interpretation
- Strong knowledge of ClinVar, dbSNP, gnomAD, HGVS nomenclature, transcript databases, and other core genomic resources
- Experience building production software that applies bioinformatics and genomic knowledge to real-world clinical or consumer genomics applications
- A passion for genetics and applying complex genomic science to build AI systems that help people better understand and improve their health
Benefits
- Comprehensive medical, dental, and vision insurance coverage
- 401(k) with company matching
- Paid time off (PTO)
- Paid volunteer time off
- Fully remote work with home office stipend
- Parental bonding leave
- Clinical-grade whole genome sequencing for you and your family (private and confidential)
Company Overview