Job Description:
• Produce innovative solutions through exploratory data analysis of complex, high-dimensional datasets
• Apply statistics, data modeling, data science, and artificial intelligence to identify patterns and opportunities
• Design, develop, and evaluate predictive models for single-gene non-invasive Fetal Screening (NIFS)
• Generate and test hypotheses from ideation through delivery
• Collaborate with R&D scientists to develop new assays, measurement technologies, and clinical tests
• Analyze genomic, transcriptomic, and proteomic datasets using bioinformatics tools and NGS pipelines
• Perform statistical and bioinformatics analyses of experimental data from DNA sequencers and molecular instruments
• Mine internally produced and publicly available datasets
• Provide analysis information to management for decisions on new laboratory developed tests
• Develop statistical classifiers and decision trees using genomic read-support and allele-dropout metrics
• Apply bioinformatics algorithms and develop novel computational approaches
• Investigate molecular-level assay limitations and define clinical reporting boundaries
• Develop and optimize complex bioinformatics analysis pipelines
• Architect production-grade Nextflow whole-genome sequencing pipelines, including caller selection, annotation strategy, and QC threshold design
• Lead bioinformatics proofs of concept for sequencer transitions, including concordance analysis, metric comparison, GIAB benchmarking, and cost-benefit recommendations
• Improve pipeline accuracy, cost of goods sold, and turnaround time
• Establish quality-control metrics and procedures for production pipelines
• Guide result interpretation and reporting standards with clinical and commercial stakeholders
• Set QC thresholds for new sample metrics and make production-impacting recommendations
Requirements:
• Ph.D. in bioinformatics, computational biology, genetics, or computer science
• 3 or more years of experience in biotechnology
• 5 or more years of experience in programming languages in bioinformatics, such as Python, R, Perl, or Java
• 5 or more years of experience with high-throughput sequencing data and bioinformatics tools like BLAST, GATK, or Bowtie
• 5 or more years of experience with Linux/Unix environments and high-performance computing (HPC) or cloud platforms
• Ability to effectively provide guidance to junior team members
• Demonstrated success in technical proficiency, scientific creativity, collaboration with others and independent thought
• Evidence of relevant research expertise through presentations, software, technical publications, and knowledge of applications
• Proficiency in data analysis and statistical learning
• Ability to exercise independent judgment in developing methods, techniques and evaluation criteria for obtaining results
Benefits:
• Annual bonus under the Labcorp Bonus Plan
• Medical insurance
• Dental insurance
• Vision insurance
• Life insurance
• Short-term disability (STD)
• Long-term disability (LTD)
• 401(k)
• Paid Time Off (PTO) or Flexible Time Off (FTO)
• Tuition Reimbursement
• Employee Stock Purchase Plan